Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6351854 | 0.79 | MAPT (0.45) | ALDH1A1SMN1; SMN2L3MBTL1KDM4ETDP1 | |
| SCHEMBL6510429 | 0.78 | HPGD (0.51) | ALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL11542037 | 0.78 | EPHX2 (0.54) | ALDH1A1SMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL638787 | 0.76 | MAPT (0.53) | SMN1; SMN2GAA | |
| SCHEMBL38662066 | 0.74 | KMT2A (0.42) | ALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL3639966 | 0.74 | KDM6B (0.43) | ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL1569112 | 0.73 | POLB (0.62) | ALDH1A1SMN1; SMN2KDM4ETDP1TP53 | |
| SCHEMBL1321921 | 0.73 | — | — | |
| SCHEMBL29410994 | 0.72 | NPC1 (0.54) | SMN1; SMN2 | |
| SCHEMBL11323934 | 0.72 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | disclosed |