Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.64 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.54 |
| ▸ | PDE6D | O43924 | 1/20 | 0.54 |
| ▸ | PDE8A | O60658 | 1/20 | 0.54 |
| ▸ | PDE9A | O76083 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | PDE6A | P16499 | 1/20 | 0.54 |
| ▸ | PDE6G | P18545 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | PDE6B | P35913 | 1/20 | 0.54 |
| ▸ | PDE6C | P51160 | 1/20 | 0.54 |
| ▸ | PDE1A | P54750 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9277180 | 0.91 | PDE5A (0.64) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL7168287 | 0.88 | PDE5A (0.67) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL7163148 | 0.80 | PDE5A (0.60) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL7721640 | 0.79 | PDE5A (0.69) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL25118239 | 0.79 | PDE5A (0.88) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL3835985 | 0.79 | PDE5A (0.68) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL7725915 | 0.78 | PDE5A (0.62) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL30199797 | 0.78 | PDE5A (1.00) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL1141 | 0.78 | PDE5A (1.00) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL9021637 | 0.77 | PDE5A (0.86) | PDE5APDE2AABCC4ABCC5PDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562830-B1 | Compounds which prevent or induce the remission of existing precancerous or cancerous lesions or carcinomas would greatly reduce illness and death from cancer | CELL PATHWAYS, INC. | 2003-05-13 | — | — | US | disclosed |
| EP-0628032-B1 | QUINAZOLINONE ANTIANGINAL AGENTS | PFIZER LTD (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1993012095-A1 | QUINAZOLINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1993-06-24 | — | — | WO | disclosed |