Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.67 |
| ▸ | PDE1A | P54750 | 8/20 | 0.64 |
| ▸ | PDE1B | Q01064 | 8/20 | 0.64 |
| ▸ | PDE1C | Q14123 | 8/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.54 |
| ▸ | PDE6D | O43924 | 1/20 | 0.54 |
| ▸ | PDE8A | O60658 | 1/20 | 0.54 |
| ▸ | PDE9A | O76083 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | PDE6A | P16499 | 1/20 | 0.54 |
| ▸ | PDE6G | P18545 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835985 | 0.91 | PDE5A (0.68) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL3841161 | 0.89 | PDE5A (0.64) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL7163161 | 0.88 | PDE5A (0.64) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL7168383 | 0.87 | PDE5A (0.66) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL3840535 | 0.85 | PDE5A (0.68) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL7167327 | 0.82 | PDE5A (0.66) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL3840503 | 0.81 | PDE5A (0.72) | PDE5APDE3BPDE3APDE1APDE1B | |
| Lodenafil SCHEMBL31202790 | 0.80 | PDE5A (1.00) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6485584 | 0.80 | PDE5A (0.81) | PDE5APDE3BPDE3APDE1APDE1B | |
| Lodenafil SCHEMBL1058 | 0.80 | PDE5A (1.00) | PDE5APDE3BPDE3APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562830-B1 | Compounds which prevent or induce the remission of existing precancerous or cancerous lesions or carcinomas would greatly reduce illness and death from cancer | CELL PATHWAYS, INC. | 2003-05-13 | — | — | US | disclosed |
| EP-0628032-B1 | QUINAZOLINONE ANTIANGINAL AGENTS | PFIZER LTD (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1993012095-A1 | QUINAZOLINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1993-06-24 | — | — | WO | disclosed |