Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 19/20 | 0.58 |
| ▸ | MMP3 | P08254 | 14/20 | 0.58 |
| ▸ | MMP13 | P45452 | 13/20 | 0.58 |
| ▸ | MMP2 | P08253 | 13/20 | 0.58 |
| ▸ | MMP7 | P09237 | 11/20 | 0.57 |
| ▸ | MMP9 | P14780 | 6/20 | 0.54 |
| ▸ | MMP8 | P22894 | 6/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7166258 | 0.98 | MMP1 (0.58) | MMP1MMP3MMP13MMP2MMP7 | |
| SCHEMBL7163665 | 0.97 | MMP1 (0.58) | MMP1MMP3MMP13MMP2MMP7 | |
| SCHEMBL7163437 | 0.97 | MMP1 (0.58) | MMP1MMP3MMP13MMP2MMP7 | |
| SCHEMBL7162262 | 0.88 | MMP1 (0.44) | MMP1MMP3MMP13MMP2MMP7 | |
| SCHEMBL7159157 | 0.83 | MMP1 (0.58) | MMP1MMP3MMP13MMP2MMP7 | |
| SCHEMBL7161303 | 0.83 | MMP1 (0.43) | MMP1MMP3MMP13MMP2MMP7 | |
| SCHEMBL7161963 | 0.81 | MMP1 (0.57) | MMP1MMP3MMP13MMP2MMP7 | |
| SCHEMBL7164719 | 0.81 | MMP1 (0.57) | MMP1MMP3MMP13MMP2MMP7 | |
| SCHEMBL7219783 | 0.79 | MMP3 (0.61) | MMP1MMP3MMP13MMP2MMP7 | |
| SCHEMBL7162466 | 0.79 | HTR6 (0.40) | MMP1MMP3MMP13MMP2MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6555535-B2 | Anticancer, antiarthritic, and antiinflammatory agents, and heart failure treatment | WARNER-LAMBERT COMPANY | 2003-04-29 | — | — | US | claimed |
| EP-1233018-A2 | Tricyclic biphenyl sulfonamide matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2002-08-21 | — | — | EP | claimed |
| US-6555535-B2 | Anticancer, antiarthritic, and antiinflammatory agents, and heart failure treatment | WARNER-LAMBERT COMPANY | 2003-04-29 | — | — | US | disclosed |
| EP-1233018-A2 | Tricyclic biphenyl sulfonamide matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2002-08-21 | — | — | EP | disclosed |