SCHEMBL716477

SCHEMBL716477

COc1cccc2[nH]c(S)nc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CBFB Q13951 2/20 0.54
ALDH1A1 P00352 2/20 0.54
CYP3A4 P08684 2/20 0.54
HPGD P15428 2/20 0.54
TP53 P04637 1/20 0.54
CYP2D6 P10635 1/20 0.54
ALOX15 P16050 1/20 0.54
CYP2C19 P33261 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
HSD17B10 Q99714 1/20 0.54
MAOB P27338 1/20 0.49
ADORA2A P29274 1/20 0.49
HPSE Q9Y251 2/20 0.48
NQO2 P16083 4/20 0.44
PDE3B Q13370 1/20 0.44
PDE3A Q14432 1/20 0.44
KEAP1 Q14145 1/20 0.43
NFE2L2 Q16236 1/20 0.43
MCHR1 Q99705 1/20 0.42
PARP1 P09874 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9306381 0.83 CBFB (0.59) CBFBALDH1A1CYP3A4HPGDTP53
SCHEMBL1170818 0.81 CBFB (0.69) CBFBALDH1A1CYP3A4HPGDTP53
SCHEMBL4611125 0.80 ALDH1A1 (0.55) CBFBALDH1A1CYP3A4HPGDTP53
SCHEMBL4420446 0.80 ALDH1A1 (0.55) CBFBALDH1A1CYP3A4HPGDTP53
SCHEMBL215705 0.79 CYP3A4 (0.54) CBFBALDH1A1CYP3A4HPGDTP53
SCHEMBL6935068 0.79 ALDH1A1 (0.54) CBFBALDH1A1CYP3A4HPGDTP53
SCHEMBL941420 0.79 HPGD (0.54) CBFBALDH1A1CYP3A4HPGDTP53
SCHEMBL6650618 0.79 CYP3A4 (0.54) CBFBALDH1A1CYP3A4HPGDTP53
SCHEMBL24276142 0.77 CBFB (0.49) CBFBALDH1A1CYP3A4HPGDTP53
SCHEMBL19170937 0.76 HSD17B10 (0.51) CBFBALDH1A1CYP3A4HPGDTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240384067-A1 CHLOROPRENE-BASED POLYMER LATEX COMPOSITION, AND DIP-MOLDED ARTICLE DENKA COMPANY LIMITED (JP) 2024-11-21 US disclosed
CN-118974159-A Impregnation-molded article, chloroprene-based polymer, and method for producing impregnation-molded article 电化株式会社 2024-11-15 CN disclosed
CN-118946622-A Process for producing chloroprene polymer composition 电化株式会社 2024-11-12 CN disclosed
CN-118946624-A Chloroprene polymer and dip-molded article 电化株式会社 2024-11-12 CN disclosed
CN-118946623-A Chloroprene polymer composition, chloroprene polymer latex, and dip-molded article 电化株式会社 2024-11-12 CN disclosed
EP-4389815-A1 CHLOROPRENE-BASED POLYMER LATEX COMPOSITION, AND DIP-MOLDED ARTICLE Denka Company Limited (JP) 2024-06-26 EP disclosed
CN-117980395-A Chloroprene type polymer latex composition and dip-molded article thereof 电化株式会社 2024-05-03 CN disclosed
WO-2023188802-A1 CHLOROPRENE-BASED POLYMER COMPOSITION, CHLOROPRENE-BASED POLYMER LATEX, AND DIP-MOLDED ARTICLE デンカ株式会社 2023-10-05 WO disclosed
WO-2023190144-A1 CHLOROPRENE POLYMER AND DIP-MOLDED PRODUCT デンカ株式会社 2023-10-05 WO disclosed
WO-2023188801-A1 METHOD FOR PRODUCING CHLOROPRENE-BASED POLYMER COMPOSITION デンカ株式会社 2023-10-05 WO disclosed
US-7425634-B2 Benzimidazole compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2008-09-16 US disclosed
US-7425634-B2 Benzimidazole compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2008-09-16 US disclosed
EP-1870409-A1 BENZIMIDAZOLE COMPOUND Eisai R&D Management Co., Ltd. (JP) 2007-12-26 EP disclosed
EP-1870409-A1 BENZIMIDAZOLE COMPOUND Eisai R&D Management Co., Ltd. (JP) 2007-12-26 EP disclosed
US-20070015782-A1 Benzimidazole compound EISAI CO., LTD. 2007-01-18 US disclosed
US-20070015782-A1 Benzimidazole compound EISAI CO., LTD. 2007-01-18 US disclosed
US-20070015782-A1 Benzimidazole compound EISAI CO., LTD. 2007-01-18 US disclosed
US-20070010542-A1 Benzimidazole compound EISAI CO., LTD. 2007-01-11 US disclosed
US-20070010542-A1 Benzimidazole compound EISAI CO., LTD. 2007-01-11 US disclosed
US-20070010542-A1 Benzimidazole compound EISAI CO., LTD. 2007-01-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070010542-A1 Benzimidazole compound HRH2, GIPR, HRH4 CBFB 4357/4885ALDH1A1 1028/4885CYP3A4 1499/4885
US-20070015782-A1 Benzimidazole compound HRH2, GIPR, HRH4 CBFB 4357/4885ALDH1A1 1028/4885CYP3A4 1499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.