Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | CBFB | Q13951 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.49 |
| ▸ | NQO2 | P16083 | 4/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974201 | 0.88 | CBFB (0.44) | ALDH1A1CYP3A4HPGDTP53CYP2D6 | |
| SCHEMBL23123180 | 0.86 | SMN1; SMN2 (0.54) | ALDH1A1CYP3A4HPGDTP53CYP2D6 | |
| SCHEMBL4611125 | 0.85 | ALDH1A1 (0.55) | ALDH1A1CYP3A4HPGDTP53CYP2D6 | |
| SCHEMBL1170818 | 0.83 | CBFB (0.69) | ALDH1A1CYP3A4HPGDTP53CYP2D6 | |
| SCHEMBL31578248 | 0.82 | ALDH1A1 (0.46) | ALDH1A1CYP3A4HPGDTP53CYP2D6 | |
| SCHEMBL18304068 | 0.80 | DRD2 (0.51) | ALDH1A1CYP3A4HPGDTP53CYP2D6 | |
| SCHEMBL941420 | 0.80 | HPGD (0.54) | ALDH1A1CYP3A4HPGDTP53CYP2D6 | |
| SCHEMBL8014752 | 0.80 | MGAM (0.43) | ALDH1A1CYP3A4HPGDTP53CYP2D6 | |
| SCHEMBL215705 | 0.80 | CYP3A4 (0.54) | ALDH1A1CYP3A4HPGDTP53CYP2D6 | |
| SCHEMBL23122996 | 0.80 | NQO2 (0.38) | ALDH1A1CYP3A4HPGDTP53CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1428510-A1 | Dyeing composition comprising a tertiary paraphenylenediamine containing a pyrrolidine, and a heterocyclic coupler or a hydroxybenzamide ; method and use | L'OREAL (FR) | 2004-06-16 | — | — | EP | claimed |
| US-20220380319-A1 | SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | BIAL R&D INVEST S A (PT) | 2022-12-01 | — | — | US | disclosed |
| EP-4031532-A1 | SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | Bial-R&D Investments, S.A. (PT) | 2022-07-27 | — | — | EP | disclosed |
| CN-114787136-A | Substituted benzimidazole carboxamides and their use in the treatment of medical disorders | 比亚尔R&D投资股份公司 | 2022-07-22 | — | — | CN | disclosed |
| WO-2021055591-A1 | SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | BIAL-BioTech Investments, Inc. (US) | 2021-03-25 | — | — | WO | disclosed |
| EP-2766359-A2 | HETEROCYCLIC COMPOUNDS AND USE THEREOF AS MODULATORS OF TYPE III RECEPTOR TYROSINE KINASES | Ambit Biosciences Corporation (US) | 2014-08-20 | — | — | EP | disclosed |
| WO-2013056070-A2 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2013-04-18 | — | — | WO | disclosed |
| US-7527953-B2 | Genes from Propionibacterium freudenreichii encoding enzymes involved in vitamin B12 biosynthesis | DSM IP ASSETS B.V. (NL) | 2009-05-05 | — | — | US | disclosed |
| US-20060183188-A1 | Genes from propionibacterium freudenreichii encoding enzymes involved in vitamin b12 biosynthesis | DSM IP ASSETS B.V. (NL) | 2006-08-17 | — | — | US | disclosed |
| EP-1525303-A1 | GENES FROM PROPIONIBACTERIUM FREUDENREICHII ENCODING ENZYMES INVOLVED IN VITAMIN B12 BIOSYNTHESIS | DSM IP Assets B.V. (NL) | 2005-04-27 | — | — | EP | disclosed |
| EP-1428510-A1 | Dyeing composition comprising a tertiary paraphenylenediamine containing a pyrrolidine, and a heterocyclic coupler or a hydroxybenzamide ; method and use | L'OREAL (FR) | 2004-06-16 | — | — | EP | disclosed |
| WO-2004011635-A1 | GENES FROM PROPIONIBACTERIUM FREUDENREICHII ENCODING ENZYMES INVOLVED IN VITAMIN B12 BIOSYNTHESIS | DSM IP ASSETS B.V. (NL) | 2004-02-05 | — | — | WO | disclosed |
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0865281-A4 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 1999-07-28 | — | — | EP | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0865281-A1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LABORATORIES, INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997021437-A1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LABORATORIES, INC. (DE) | 1997-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183188-A1 | Genes from propionibacterium freudenreichii encoding enzymes involved in vitamin b12 biosynthesis | COASY, AMD1, BLVRB | ALDH1A1 1176/4885CYP3A4 2019/4885HPGD 179/4885 |
| US-20220380319-A1 | SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | GAA, GBA1, CLN6 | ALDH1A1 1096/4885CYP3A4 1710/4885HPGD 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.