Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 6/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.35 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LAP3 | P28838 | 2/20 | 0.31 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5662268 | 1.00 | TSHR (0.41) | TSHRLMNAALDH1A1MAPK1SLC7A5 | |
| SCHEMBL9546948 | 0.78 | LMNA (0.42) | TSHRLMNAALDH1A1MAPK1THRB | |
| SCHEMBL1203940 | 0.76 | TSHR (0.43) | TSHRLMNAALDH1A1MAPK1SLC7A5 | |
| SCHEMBL1204837 | 0.76 | TSHR (0.43) | TSHRLMNAALDH1A1MAPK1SLC7A5 | |
| SCHEMBL14343956 | 0.76 | TSHR (0.43) | TSHRLMNAALDH1A1MAPK1SLC7A5 | |
| SCHEMBL1927205 | 0.76 | — | — | |
| SCHEMBL1285795 | 0.75 | LMNA (0.47) | LMNAALDH1A1THRB | |
| SCHEMBL379036 | 0.75 | THRB (0.42) | LMNATHRB | |
| SCHEMBL288820 | 0.75 | LMNA (0.47) | LMNAALDH1A1THRB | |
| Hydrochloric Acid SCHEMBL1927803 | 0.74 | LMNA (0.41) | TSHRLMNAALDH1A1MAPK1SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789578-B1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-0789578-A4 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2000-09-20 | — | — | EP | disclosed |
| US-5990083-A | Multicatalytic protease inhibitors | CEPHALON, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5830870-A | PREVENT LOSS OF MUSCLE MASS | CEPHALON, INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0789578-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1997-08-20 | — | — | EP | disclosed |
| US-5614649-A | TREATMENT OF MUSCULAR DISORDERS, SUBSTITUTED GUANIDINES | CEPHALON, INC. (US) | 1997-03-25 | — | — | US | disclosed |
| US-5550262-A | TREATMENT OF MUSCLES WASTING DISEASES | CEPHALON, INC. (US) | 1996-08-27 | — | — | US | disclosed |
| WO-1996014857-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1996-05-23 | — | — | WO | disclosed |