Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | NOS1 | P29475 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | MAOB | P27338 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | XDH | P47989 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL7166295 | 0.93 | MAPT (0.68) | MAPTNOS1POLBMAOBCYP3A4 | |
| Nitric Acid SCHEMBL4907401 | 0.87 | CYP3A4 (0.71) | MAPTNOS1POLBMAOBCYP3A4 | |
| SCHEMBL271340 | 0.83 | CYP3A4 (0.77) | MAPTNOS1POLBMAOBCYP3A4 | |
| SCHEMBL29923659 | 0.83 | CYP3A4 (0.77) | MAPTNOS1POLBMAOBCYP3A4 | |
| SCHEMBL148826 | 0.83 | NOS1 (1.00) | MAPTNOS1POLBMAOBCYP3A4 | |
| Bromide SCHEMBL8520491 | 0.81 | NOS1 (0.97) | MAPTNOS1POLBMAOBCYP3A4 | |
| Hydrochloric Acid SCHEMBL31587195 | 0.81 | NOS1 (0.97) | MAPTNOS1POLBMAOBCYP3A4 | |
| SCHEMBL8425555 | 0.81 | CYP3A4 (0.75) | MAPTNOS1POLBMAOBCYP3A4 | |
| Silver SCHEMBL11230934 | 0.81 | CYP3A4 (0.75) | MAPTNOS1POLBMAOBCYP3A4 | |
| SCHEMBL17291792 | 0.80 | NOS1 (0.82) | MAPTNOS1POLBMAOBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360551-A2 | DIGITAL FILM PROCESSING SOLUTIONS AND METHOD OF DIGITAL FILM PROCESSING | Applied Science Fiction, Inc. (US) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002065210-A2 | DIGITAL FILM PROCESSING SOLUTIONS AND METHOD OF DIGITAL FILM PROCESSING | EASTMAN KODAK COMPANY (US) | 2002-08-22 | — | — | WO | disclosed |