Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 6/20 | 0.50 |
| ▸ | AR | P10275 | 4/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 5/20 | 0.37 |
| ▸ | USP7 | Q93009 | 3/20 | 0.37 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | ESRRB | O95718 | 1/20 | 0.35 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450852 | 0.76 | ESR2 (0.68) | ESR2ARMMP3ESR1SENP1 | |
| SCHEMBL4421994 | 0.73 | MMP3 (0.44) | ARMMP3CA12CA2CA3 | |
| SCHEMBL12801483 | 0.71 | SENP1 (0.43) | ESR2ESR1USP7SENP1 | |
| SCHEMBL13807442 | 0.70 | TSHR (0.43) | AR | |
| SCHEMBL14173712 | 0.69 | AR (0.50) | ESR2ARMMP3ESR1USP7 | |
| SCHEMBL2785589 | 0.68 | AR (0.57) | ESR2ARMMP3ESR1 | |
| SCHEMBL1532429 | 0.67 | ESR2 (1.00) | ESR2ARMMP3CYP19A1ESR1 | |
| SCHEMBL14675564 | 0.67 | ESR2 (0.43) | ESR2ARMMP3CYP19A1ESR1 | |
| SCHEMBL4667162 | 0.67 | ESR2 (0.59) | ESR2ARMMP3CYP19A1ESR1 | |
| SCHEMBL4650125 | 0.66 | ESR1 (0.48) | ESR2ARESR1USP7SENP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370546-A2 | NOVEL AMINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | Abbott Laboratories (US) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074758-A2 | NOVEL AMINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2002-09-26 | — | — | WO | disclosed |