Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | DRD1 | P21728 | 3/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15908320 | 0.68 | OPRM1 (0.62) | SLC6A2OPRM1CHRM2CHRM1SLC6A4 | |
| SCHEMBL17655192 | 0.68 | SLC6A2 (0.41) | SLC6A2OPRM1CHRM2CHRM1SLC6A4 | |
| SCHEMBL2604390 | 0.68 | MAOA (0.52) | SLC6A2OPRM1CHRM2CHRM1SLC6A4 | |
| SCHEMBL18120574 | 0.67 | SLC6A2 (0.39) | SLC6A2OPRM1CHRM2CHRM1SLC6A4 | |
| SCHEMBL20707863 | 0.67 | ALDH1A1 (0.48) | SLC6A2OPRM1CHRM2CHRM1SLC6A4 | |
| SCHEMBL31091227 | 0.67 | NOTUM (0.56) | SLC6A2OPRM1CHRM2CHRM1SLC6A4 | |
| SCHEMBL15908341 | 0.67 | OPRM1 (0.65) | SLC6A2OPRM1CHRM2CHRM1SLC6A4 | |
| SCHEMBL18019505 | 0.66 | OPRM1 (0.62) | OPRM1NOTUMOPRK1OPRL1 | |
| SCHEMBL12992625 | 0.66 | HPGD (0.50) | SLC6A2OPRM1CHRM2CHRM1SLC6A4 | |
| SCHEMBL13723399 | 0.66 | POLB (0.47) | SLC6A2OPRM1CHRM2CHRM1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6569849-B1 | N-Substituted azaheterocyclic compounds | NOVO NORDISK A/S (DK) | 2003-05-27 | — | — | US | disclosed |
| EP-0934306-A1 | N-SUBSTITUTED AZAHETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998015546-A1 | N-SUBSTITUTED AZAHETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-04-16 | — | — | WO | disclosed |