Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNN4 | O15554 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358191 | 0.85 | ALDH1A1 (0.67) | HTTTSHRALDH1A1CHRM3KCNH2 | |
| SCHEMBL8661754 | 0.82 | OPRM1 (0.57) | HTTTSHRALDH1A1CHRM3KCNH2 | |
| SCHEMBL8071145 | 0.79 | CHRM3 (0.50) | HTTTSHRALDH1A1CHRM3KCNH2 | |
| SCHEMBL15848242 | 0.77 | ALDH1A1 (0.53) | HTTTSHRALDH1A1CHRM3CHRM2 | |
| SCHEMBL11021099 | 0.76 | MAPT (0.52) | HTTTSHRCHRM3KCNH2CHRM2 | |
| SCHEMBL3465944 | 0.76 | HTT (0.81) | HTTTSHRALDH1A1CHRM3KCNH2 | |
| SCHEMBL3465945 | 0.76 | HTT (0.81) | HTTTSHRALDH1A1CHRM3KCNH2 | |
| SCHEMBL1908316 | 0.76 | ALDH1A1 (0.65) | HTTTSHRALDH1A1CYP2D6KMT2A | |
| SCHEMBL3613086 | 0.76 | ALDH1A1 (0.65) | HTTTSHRALDH1A1CYP2D6KMT2A | |
| SCHEMBL10685798 | 0.75 | CHRM3 (0.50) | HTTTSHRCHRM3KCNH2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6573282-B1 | Compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors | ADOLOR CORPORATION | 2003-06-03 | — | — | US | disclosed |
| US-5994372-A | ANTIDIARRHEA COMPOUND | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0852494-A2 | PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-07-15 | — | — | EP | disclosed |
| WO-1997009973-A2 | PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-03-20 | — | — | WO | disclosed |