Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 10/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 2/20 | 0.35 |
| ▸ | FNTB | P49356 | 2/20 | 0.35 |
| ▸ | FABP3 | P05413 | 3/20 | 0.33 |
| ▸ | FABP4 | P15090 | 3/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087587 | 0.89 | FABP3 (0.39) | RORCFNTAFNTBFABP3FABP4 | |
| SCHEMBL7191222 | 0.86 | FNTA (0.45) | RORCNR1I3FNTAFNTBFABP3 | |
| SCHEMBL7166191 | 0.73 | RORC (0.42) | RORCFNTAFNTB | |
| SCHEMBL7090215 | 0.69 | FNTA (0.48) | RORCFNTAFNTB | |
| SCHEMBL7093338 | 0.68 | MAPT (0.38) | FNTAFNTBFABP3FABP4FABP5 | |
| SCHEMBL7094552 | 0.66 | IDO1 (0.48) | RORCFNTAFNTBFABP3FABP4 | |
| SCHEMBL6987223 | 0.66 | IDO1 (0.48) | RORCFNTAFNTBFABP3FABP4 | |
| SCHEMBL7088398 | 0.66 | FNTA (0.47) | FNTAFNTBFABP3FABP4FABP5 | |
| SCHEMBL7093092 | 0.65 | FNTA (0.44) | RORCFNTAFNTB | |
| SCHEMBL14588478 | 0.64 | FNTA (0.75) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322636-A1 | FARNESYL TRANSFERASE INHIBITING 6- (SUBSTITUTED PHENYL)METHYL]-QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024683-A1 | FARNESYL TRANSFERASE INHIBITING 6-[(SUBSTITUTED PHENYL)METHYL]-QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | disclosed |