Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2417510 | 0.84 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL7171142 | 0.81 | NAAA (0.46) | NAAATSHRMAPK1TP53CYP3A4 | |
| SCHEMBL7064301 | 0.78 | — | — | |
| SCHEMBL7172041 | 0.78 | TSHR (0.34) | NAAATSHRMAPK1TP53CYP3A4 | |
| SCHEMBL7066417 | 0.73 | — | — | |
| SCHEMBL9000091 | 0.73 | EGFR (0.32) | — | |
| SCHEMBL4566315 | 0.71 | TSHR (0.39) | TSHRMAPK1ALDH1A1LMNAFAAH | |
| SCHEMBL5158940 | 0.71 | ALDH1A1 (0.47) | NAAATSHRMAPK1EPHX1ALDH1A1 | |
| SCHEMBL14759196 | 0.67 | NAAA (0.50) | NAAATSHRMAPK1TP53CYP3A4 | |
| SCHEMBL11510271 | 0.67 | NAAA (0.55) | NAAATSHREPHX1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028721-B1 | N,N'-BIS(SULFONYL)HYDRAZINES USEFUL AS ANTINEOPLASTIC AGENTS | UNIV YALE (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-1028721-A4 | N,N'-BIS(SULFONYL)HYDRAZINES USEFUL AS ANTINEOPLASTIC AGENTS | UNIV YALE (US) | 2001-01-31 | — | — | EP | disclosed |
| EP-1028721-A1 | $i(N,N')-BIS(SULFONYL)HYDRAZINES USEFUL AS ANTINEOPLASTIC AGENTS | Yale University (US) | 2000-08-23 | — | — | EP | disclosed |
| US-6040338-A | N,n-bis(sulfonyl)hydrazines useful as antineoplastic agents | YALE UNIVERSITY (US) | 2000-03-21 | — | — | US | disclosed |
| WO-1999022726-A1 | N,N'-BIS(SULFONYL)HYDRAZINES USEFUL AS ANTINEOPLASTIC AGENTS | YALE UNIVERSITY (US) | 1999-05-14 | — | — | WO | disclosed |