Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 3/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674864 | 0.80 | LMNA (0.43) | LMNAALDH1A1HTTSMN1; SMN2CYP1A2 | |
| SCHEMBL4884796 | 0.73 | MAPT (0.50) | LMNAALDH1A1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL27530283 | 0.72 | LMNA (0.49) | LMNAALDH1A1HTTSMN1; SMN2CYP1A2 | |
| SCHEMBL8055184 | 0.71 | TDP1 (0.43) | ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL28598667 | 0.69 | SMN1; SMN2 (0.47) | LMNAALDH1A1HTTSMN1; SMN2CYP1A2 | |
| SCHEMBL30464734 | 0.68 | ALDH1A1 (0.66) | LMNAALDH1A1HTTSMN1; SMN2CYP1A2 | |
| SCHEMBL12128754 | 0.68 | MAPT (0.52) | LMNAALDH1A1HTTSMN1; SMN2CYP1A2 | |
| SCHEMBL8217660 | 0.68 | MAPT (0.45) | LMNAALDH1A1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL2461666 | 0.68 | ALDH1A1 (0.66) | LMNAALDH1A1HTTSMN1; SMN2CYP1A2 | |
| SCHEMBL27763626 | 0.68 | ALDH1A1 (0.52) | LMNAALDH1A1SMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657166-B1 | Combination containing a quinoxaline and a nucleoside | AVENTIS PHARMA GMBH (DE) | 2003-04-09 | — | — | EP | disclosed |
| EP-0509398-B1 | Quinoxalines, process for their preparation and their use | AVENTIS PHARMA GMBH (DE) | 2001-09-19 | — | — | EP | disclosed |
| EP-0509398-A1 | Quinoxalines, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-10-21 | — | — | EP | disclosed |