Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25360224 | 0.83 | RAB9A (0.52) | RAB9AALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL9980861 | 0.83 | NOTUM (0.46) | NOTUMRAB9AHTTALDH1A1MAPT | |
| SCHEMBL7192842 | 0.77 | NOTUM (0.45) | NOTUMRAB9AHTTALDH1A1MAPT | |
| SCHEMBL7193264 | 0.77 | NOTUM (0.47) | NOTUMRAB9AHTTALDH1A1MAPT | |
| SCHEMBL914428 | 0.76 | HPGD (0.53) | NOTUMRAB9AALDH1A1MAPTTDP1 | |
| SCHEMBL12048166 | 0.74 | NOTUM (0.47) | NOTUMRAB9AHTTALDH1A1MAPT | |
| SCHEMBL12049141 | 0.74 | NOTUM (0.47) | NOTUMRAB9AHTTALDH1A1MAPT | |
| SCHEMBL465889 | 0.74 | NOTUM (0.47) | NOTUMRAB9AALDH1A1MAPTLMNA | |
| SCHEMBL10344443 | 0.74 | ELANE (0.66) | NOTUMRAB9AALDH1A1MAPTLMNA | |
| SCHEMBL465868 | 0.74 | MEN1 (0.50) | NOTUMRAB9AMAPTLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007955-A2 | BIPHENYL APURINIC/APYRIMIDINIC SITE ENDONUCLEASE INHIBITORS TO TREAT CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2003-01-30 | — | — | WO | claimed |