Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | ELANE | P08246 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | C1R | P00736 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7170099 | 0.83 | NOTUM (0.45) | RAB9ANPC1ELANEKDM4EALDH1A1 | |
| SCHEMBL22952937 | 0.78 | NPC1 (0.51) | RAB9ANPC1ELANERXFP1KDM4E | |
| SCHEMBL13587068 | 0.77 | ELANE (0.54) | RAB9ANPC1ELANERXFP1KDM4E | |
| SCHEMBL913895 | 0.77 | NPC1 (0.70) | RAB9ANPC1ELANERXFP1KDM4E | |
| SCHEMBL12744508 | 0.72 | NPC1 (0.73) | RAB9ANPC1ELANERXFP1KDM4E | |
| SCHEMBL25361146 | 0.72 | RAB9A (0.48) | RAB9AELANEMAOBRXFP1KDM4E | |
| SCHEMBL25363387 | 0.72 | TNKS (0.58) | RAB9ANPC1KDM4EALDH1A1POLB | |
| SCHEMBL25359782 | 0.72 | ADORA2B (0.43) | MAOBKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL30494909 | 0.72 | ADORA2B (0.43) | MAOBKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL11813493 | 0.71 | NPC1 (0.75) | RAB9ANPC1ELANERXFP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |