Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31388678 | 1.00 | TSHR (0.55) | TSHRHSP90AA1CRHBPCRHR2NCEH1 | |
| SCHEMBL9670565 | 0.83 | HSP90AA1 (0.50) | TSHRHSP90AA1CRHBPCRHR2NCEH1 | |
| SCHEMBL12327748 | 0.80 | ALDH1A1 (0.46) | HSP90AA1CRHBPCRHR2NCEH1ALDH1A1 | |
| SCHEMBL12298750 | 0.80 | MAPT (0.43) | HSP90AA1CRHBPCRHR2ALDH1A1KDM4E | |
| SCHEMBL9670567 | 0.79 | ALDH1A1 (0.53) | TSHRHSP90AA1CRHBPCRHR2NCEH1 | |
| SCHEMBL10576662 | 0.78 | HSD17B10 (0.50) | TSHRHSP90AA1CRHBPCRHR2NCEH1 | |
| SCHEMBL10576656 | 0.78 | HSD17B10 (0.50) | TSHRHSP90AA1CRHBPCRHR2NCEH1 | |
| Phosphonic Acid SCHEMBL27293071 | 0.78 | TSHR (0.54) | TSHRHSP90AA1CRHBPCRHR2NCEH1 | |
| SCHEMBL20436327 | 0.77 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPTHPGDGLA | |
| SCHEMBL10575249 | 0.77 | TRPV1 (0.54) | TSHRHSP90AA1CRHBPCRHR2NCEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1297835-A1 | Benzo[b]pyrano[3,2-h]acridin-7-one derivatives, processes for their preparation and pharmaceutical compositions thereof | LES LABORATOIRES SERVIER (FR) | 2003-04-02 | — | — | EP | disclosed |
| EP-1025101-B1 | NAPHTHO-IMIDAZO 1,2-A]PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO MCNEIL PHARM INC (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6200984-B1 | BINDERS FOR G-AMINOBUTYRIC ACID RECEPTORS; ANXIOLYTIC AGENTS, ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-1025101-A1 | NAPHTHO-IMIDAZO 1,2-A]PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999018104-A1 | NAPHTHO-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-04-15 | — | — | WO | disclosed |