Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670567 | 0.85 | ALDH1A1 (0.53) | HSP90AA1CRHBPCRHR2TSHRNCEH1 | |
| SCHEMBL7170274 | 0.83 | TSHR (0.55) | HSP90AA1CRHBPCRHR2TSHRNCEH1 | |
| SCHEMBL31388678 | 0.83 | TSHR (0.55) | HSP90AA1CRHBPCRHR2TSHRNCEH1 | |
| SCHEMBL9362554 | 0.82 | HSP90AA1 (0.39) | HSP90AA1CRHBPCRHR2NCEH1ALDH1A1 | |
| SCHEMBL9670984 | 0.81 | KMT2A (0.40) | TSHRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL9669306 | 0.80 | KCNJ11 (0.46) | NPSR1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9398069 | 0.79 | ALDH1A1 (0.62) | TSHRCYP3A4NPSR1ALDH1A1HPGD | |
| SCHEMBL9746874 | 0.78 | HSP90AA1 (0.46) | HSP90AA1CRHBPCRHR2ALDH1A1KMT2A | |
| SCHEMBL8609981 | 0.75 | HSP90AA1 (0.49) | HSP90AA1CRHBPCRHR2TSHRNCEH1 | |
| SCHEMBL10576656 | 0.74 | HSD17B10 (0.50) | HSP90AA1CRHBPCRHR2TSHRNCEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283959-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-01-02 | — | — | EP | disclosed |
| US-4912108-A | Containing hydroxy substitution | A/S FERROSAN (DK) | 1990-03-27 | — | — | US | disclosed |
| US-4889855-A | ADMINISTERING GLUTAMATE ANTAGONIST TO INHIBIT HYPERACTIVITY OF EXCITATORY NEUROTRANSMITTERS | A/S FERROSAN (DK) | 1989-12-26 | — | — | US | disclosed |
| EP-0283959-A1 | Heterocyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1988-09-28 | — | — | EP | disclosed |