Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670565 | 0.85 | HSP90AA1 (0.50) | ALDH1A1KMT2AHSP90AA1CRHBPCRHR2 | |
| SCHEMBL9362558 | 0.84 | ALDH1A1 (0.52) | ALDH1A1KMT2AHSP90AA1CRHBPCRHR2 | |
| SCHEMBL9671752 | 0.82 | ALDH1A1 (0.50) | ALDH1A1KMT2AGPR35GAAL3MBTL1 | |
| SCHEMBL9746877 | 0.80 | KMT2A (0.48) | ALDH1A1KMT2AHSP90AA1CRHBPCRHR2 | |
| SCHEMBL31388678 | 0.79 | TSHR (0.55) | ALDH1A1KMT2AHSP90AA1CRHBPCRHR2 | |
| SCHEMBL7170274 | 0.79 | TSHR (0.55) | ALDH1A1KMT2AHSP90AA1CRHBPCRHR2 | |
| SCHEMBL9398072 | 0.79 | ALDH1A1 (0.73) | ALDH1A1KMT2AGPR35GAAL3MBTL1 | |
| SCHEMBL7484286 | 0.79 | TOP2A (0.52) | ALDH1A1HSP90AA1CRHBPCRHR2TSHR | |
| SCHEMBL16238997 | 0.77 | CDC25B (0.53) | ALDH1A1KMT2AHSP90AA1CRHBPCRHR2 | |
| SCHEMBL3641699 | 0.77 | ALDH1A1 (0.60) | ALDH1A1KMT2AGPR35GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283959-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-01-02 | — | — | EP | disclosed |
| US-4912108-A | Containing hydroxy substitution | A/S FERROSAN (DK) | 1990-03-27 | — | — | US | disclosed |
| US-4889855-A | ADMINISTERING GLUTAMATE ANTAGONIST TO INHIBIT HYPERACTIVITY OF EXCITATORY NEUROTRANSMITTERS | A/S FERROSAN (DK) | 1989-12-26 | — | — | US | disclosed |
| EP-0283959-A1 | Heterocyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1988-09-28 | — | — | EP | disclosed |