Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.58 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | IL6 | P05231 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7170445 | 1.00 | ALDH1A1 (0.66) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL12948731 | 0.93 | ALDH1A1 (0.76) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL12948685 | 0.86 | MAPT (0.84) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL7273033 | 0.82 | ALDH1A1 (0.51) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL31190489 | 0.82 | ACHE (0.63) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL809614 | 0.81 | ALDH1A1 (0.65) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL28394403 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL7328466 | 0.76 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL9740855 | 0.76 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL7328464 | 0.76 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007955-A2 | BIPHENYL APURINIC/APYRIMIDINIC SITE ENDONUCLEASE INHIBITORS TO TREAT CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2003-01-30 | — | — | WO | claimed |