Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.54 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.54 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.54 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.47 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27378863 | 0.84 | ROCK2 (0.60) | AXLGABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7176319 | 0.84 | EGFR (0.55) | PTGER1PTGER4PTGER3PTGER2TSHR | |
| SCHEMBL29956264 | 0.84 | PTGER1 (0.54) | PTGER1PTGER4PTGER3PTGER2ENPP2 | |
| SCHEMBL28755028 | 0.84 | TSHR (0.60) | AXLGABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7173368 | 0.83 | MTNR1A (0.50) | AXLGABRG2GABRB3GABRA5GABRA3 | |
| Methane SCHEMBL28667111 | 0.82 | TSHR (0.58) | AXLGABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL4304231 | 0.81 | ALDH1A1 (0.59) | TSHRRAB9ANPC1 | |
| SCHEMBL6736858 | 0.80 | EGFR (0.56) | AXLGABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1221576 | 0.78 | TSHR (0.67) | AXLGABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL29410906 | 0.78 | TSHR (0.67) | AXLGABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576632-B1 | Such as 3'-((Benzyl-(2-benzyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-carbamoyl)-methyl)-biphenyl-3-carboxylic acid | PFIZER INC | 2003-06-10 | — | — | US | disclosed |