Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 16/20 | 0.55 |
| ▸ | MMP1 | P03956 | 14/20 | 0.55 |
| ▸ | MMP9 | P14780 | 3/20 | 0.55 |
| ▸ | FCER2 | P06734 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 5/20 | 0.46 |
| ▸ | MMP7 | P09237 | 2/20 | 0.46 |
| ▸ | MMP8 | P22894 | 2/20 | 0.46 |
| ▸ | TNF | P01375 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.46 |
| ▸ | MMP20 | O60882 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | MMP10 | P09238 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | MMP15 | P51511 | 1/20 | 0.46 |
| ▸ | MMP16 | P51512 | 1/20 | 0.46 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.46 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7177123 | 0.97 | MMP3 (0.57) | MMP3MMP1MMP9FCER2PPARG | |
| SCHEMBL7172616 | 0.91 | MMP3 (0.46) | MMP3MMP1MMP9FCER2PPARG | |
| SCHEMBL7174311 | 0.88 | MMP3 (0.48) | MMP3MMP1MMP9PPARG | |
| SCHEMBL7170041 | 0.86 | MMP3 (0.52) | MMP3MMP1MMP9FCER2PPARG | |
| SCHEMBL7172650 | 0.85 | NPC1 (0.47) | MMP3MMP1MMP9PPARG | |
| SCHEMBL7177702 | 0.84 | MMP3 (0.50) | MMP3MMP1MMP9PPARGMMP2 | |
| SCHEMBL7178370 | 0.83 | PPARG (0.46) | MMP3MMP1MMP9PPARG | |
| SCHEMBL7170096 | 0.83 | FCER2 (0.50) | MMP3MMP1MMP9FCER2MMP2 | |
| SCHEMBL7172189 | 0.81 | PPARG (0.44) | MMP3MMP1MMP9PPARGMMP2 | |
| SCHEMBL7177453 | 0.80 | MMP3 (0.55) | MMP3MMP1MMP9FCER2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576628-B1 | Matrix metalloprotease inhibitors; arthritis, corneal ulcers, arteriosclerosis | ROCHE DIAGNOSTICS GMBH (DE) | 2003-06-10 | — | — | US | disclosed |
| EP-1005449-B1 | 3-ARYL-SUCCINAMIDO-HYDROXAMIC ACIDS, METHODS FOR PRODUCING SAID ACIDS AND MEDICAMENTS CONTAINING THE SAME | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-30 | — | — | EP | disclosed |
| EP-0897908-A1 | 3-Aryl-succinamido-hydroxamic acids, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1999-02-24 | — | — | EP | disclosed |