Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 12/20 | 0.50 |
| ▸ | MMP1 | P03956 | 11/20 | 0.50 |
| ▸ | MMP9 | P14780 | 4/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP7 | P09237 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7170041 | 0.97 | MMP3 (0.52) | MMP3MMP1MMP9MMP2MMP7 | |
| SCHEMBL7173112 | 0.93 | MMP1 (0.44) | MMP3MMP1MMP9MMP2MMP7 | |
| SCHEMBL7177674 | 0.90 | MMP1 (0.46) | MMP3MMP1MMP9MMP2MMP7 | |
| SCHEMBL7177123 | 0.87 | MMP3 (0.57) | MMP3MMP1MMP9MMP2MMP7 | |
| SCHEMBL7178504 | 0.86 | MMP3 (0.45) | MMP3MMP1MMP9MMP2MMP7 | |
| SCHEMBL7172740 | 0.86 | MMP3 (0.52) | MMP3MMP1MMP9MMP2MMP7 | |
| SCHEMBL7172185 | 0.84 | MMP3 (0.55) | MMP3MMP1MMP9MMP2MMP7 | |
| SCHEMBL7178513 | 0.83 | MMP1 (0.44) | MMP3MMP1MMP9MMP2 | |
| SCHEMBL7192046 | 0.83 | MMP3 (0.52) | MMP3MMP1MMP9MMP2MMP7 | |
| SCHEMBL7178370 | 0.79 | PPARG (0.46) | MMP3MMP1MMP9PPARGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576628-B1 | Matrix metalloprotease inhibitors; arthritis, corneal ulcers, arteriosclerosis | ROCHE DIAGNOSTICS GMBH (DE) | 2003-06-10 | — | — | US | disclosed |
| EP-1005449-B1 | 3-ARYL-SUCCINAMIDO-HYDROXAMIC ACIDS, METHODS FOR PRODUCING SAID ACIDS AND MEDICAMENTS CONTAINING THE SAME | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-30 | — | — | EP | disclosed |
| EP-0897908-A1 | 3-Aryl-succinamido-hydroxamic acids, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1999-02-24 | — | — | EP | disclosed |