Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 5/20 | 0.50 |
| ▸ | NOS1 | P29475 | 4/20 | 0.50 |
| ▸ | NOS3 | P29474 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GSR | P00390 | 1/20 | 0.47 |
| ▸ | OTC | P00480 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.44 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | ARG1 | P05089 | 3/20 | 0.43 |
| ▸ | ARG2 | P78540 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7915399 | 1.00 | NOS2 (0.50) | NOS2NOS1NOS3CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL7218895 | 0.98 | NOS2 (0.51) | NOS2NOS1NOS3CYP1A2CYP3A4 | |
| SCHEMBL7227260 | 0.85 | DPP7 (0.42) | NOS2NOS1NOS3CYP1A2CYP3A4 | |
| SCHEMBL7227075 | 0.85 | NOD1 (0.50) | NOD1DPP7 | |
| SCHEMBL7227064 | 0.85 | NOD1 (0.50) | NOD1DPP7 | |
| SCHEMBL7221210 | 0.84 | DPP7 (0.43) | NOS2NOS1NOS3CYP1A2CYP3A4 | |
| SCHEMBL7221219 | 0.84 | DPP7 (0.43) | NOS2NOS1NOS3CYP1A2CYP3A4 | |
| SCHEMBL9296642 | 0.84 | NOS2 (0.47) | NOS2NOS1NOS3CYP1A2CYP3A4 | |
| SCHEMBL7227262 | 0.83 | DPP7 (0.37) | NOS2NOS1NOS3CYP1A2CYP3A4 | |
| SCHEMBL7908788 | 0.83 | NOS2 (0.46) | NOS2NOS1NOS3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966286-B1 | ATTENUATION OF OPIOID TOLERANCE BY INHIBITING INDUCIBLE NITRIC OXIDE SYNTHASE PATHWAYS IN THE TREATMENT OF PAIN | SEARLE & CO (US) | 2003-07-30 | — | — | EP | claimed |
| JP-2001508444-A | — | — | 2001-06-26 | — | — | JP | claimed |
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | claimed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | claimed |
| EP-0966286-A1 | ATTENUATION OF OPIOID TOLERANCE BY INHIBITING INDUCIBLE NITRIC OXIDE SYNTHASE PATHWAYS IN THE TREATMENT OF PAIN | G.D. SEARLE & CO. (US) | 1999-12-29 | — | — | EP | claimed |
| EP-0885188-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-12-23 | — | — | EP | claimed |
| WO-1998030220-A1 | ATTENUATION OF OPIOID TOLERANCE BY INHIBITING INDUCIBLE NITRIC OXIDE SYNTHASE PATHWAYS IN THE TREATMENT OF PAIN | G.D. SEARLE & CO. (US) | 1998-07-16 | — | — | WO | claimed |
| WO-1997032844-A9 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | — | 1997-12-24 | — | — | WO | claimed |
| WO-1997032844-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-09-12 | — | — | WO | claimed |
| US-6576780-B1 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors | GD SEARLE & COMPANY | 2003-06-10 | — | — | US | disclosed |
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | disclosed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | disclosed |
| EP-0966286-A1 | ATTENUATION OF OPIOID TOLERANCE BY INHIBITING INDUCIBLE NITRIC OXIDE SYNTHASE PATHWAYS IN THE TREATMENT OF PAIN | G.D. SEARLE & CO. (US) | 1999-12-29 | — | — | EP | disclosed |
| EP-0885188-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1998030220-A1 | ATTENUATION OF OPIOID TOLERANCE BY INHIBITING INDUCIBLE NITRIC OXIDE SYNTHASE PATHWAYS IN THE TREATMENT OF PAIN | G.D. SEARLE & CO. (US) | 1998-07-16 | — | — | WO | disclosed |
| WO-1997032844-A9 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | — | 1997-12-24 | — | — | WO | disclosed |
| WO-1997032844-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-09-12 | — | — | WO | disclosed |