Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7175448 | 0.86 | PDE5A (0.42) | SMN1; SMN2MAPTIDO1ALDH1A1KDM4E | |
| SCHEMBL5904052 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2AUSP2CASP1 | |
| SCHEMBL1168220 | 0.80 | IDO1 (0.52) | SMN1; SMN2MEN1KMT2AUSP2CASP1 | |
| SCHEMBL9306024 | 0.79 | LMNA (0.46) | SMN1; SMN2MEN1KMT2AUSP2CASP1 | |
| SCHEMBL7186538 | 0.79 | SMN1; SMN2 (0.40) | SMN1; SMN2MEN1KMT2AUSP2MAPT | |
| SCHEMBL18415207 | 0.78 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2AUSP2CASP1 | |
| SCHEMBL3904434 | 0.78 | QPCT (0.49) | SMN1; SMN2MEN1KMT2AUSP2CASP1 | |
| SCHEMBL9196333 | 0.78 | SLC6A4 (0.44) | SMN1; SMN2MEN1KMT2AUSP2CASP1 | |
| SCHEMBL27570780 | 0.77 | ALDH1A1 (0.37) | SMN1; SMN2MEN1KMT2AMAPTRAB9A | |
| SCHEMBL7770001 | 0.77 | STAT3 (0.48) | SMN1; SMN2MEN1KMT2AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576664-B1 | 1-amido-2-hydroxy-substituted-indanes; suppressing production of tumor necrosis factor | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-06-10 | — | — | US | disclosed |