Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7124281 | 0.82 | TERT (0.42) | KDM4EALDH1A1HTTGAAMEN1 | |
| SCHEMBL7171188 | 0.82 | MEN1 (0.51) | KDM4EALDH1A1HTTGAAMEN1 | |
| SCHEMBL8396114 | 0.80 | ALDH1A1 (0.40) | KDM4EALDH1A1HTTACHEGAA | |
| SCHEMBL8398430 | 0.79 | CA1 (0.43) | KDM4EALDH1A1HTTGAAMEN1 | |
| SCHEMBL7174644 | 0.77 | ALDH1A1 (0.39) | KDM4EALDH1A1HTTGAAMEN1 | |
| SCHEMBL8393467 | 0.71 | ALDH1A1 (0.42) | KDM4EALDH1A1HTTGAAMEN1 | |
| SCHEMBL10676572 | 0.70 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDGAAMEN1 | |
| SCHEMBL6243924 | 0.70 | ALDH1A1 (0.68) | KDM4EALDH1A1HPGDGAAMEN1 | |
| SCHEMBL8520467 | 0.69 | KDM4E (0.59) | KDM4EHTTBCHEACHEMEN1 | |
| SCHEMBL30300553 | 0.67 | MEN1 (0.62) | ALDH1A1HTTGAAMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030040028-A1 | Analgesic screening method and composition | MILLER JAMES L (US) | 2003-02-27 | — | — | US | disclosed |
| US-6489119-B1 | SELECTING ANALGESIC AGENTS BASED ON THEIR SELECTIVE ABILITY TO BLOCK TETRODOTOXIN-INSENSITIVE SODIUM CHANNELS, PARTICULARLY IN COMPARISON TO BLOCKING TETRODOTOXIN-SENSITIVE SODIUM CHANNELS. ALSO DISCLOSED IS A NOVEL CLASS OF COMPOUNDS | ELAN PHARMACEUTICALS, INC. | 2002-12-03 | — | — | US | disclosed |
| EP-0915834-A1 | METHOD AND COMPOSITIONS FOR PRODUCING ANALGESIA | ELAN PHARMACEUTICALS, INC. (US) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997033860-A1 | METHOD AND COMPOSITIONS FOR PRODUCING ANALGESIA | NEUREX CORPORATION (US) | 1997-09-18 | — | — | WO | disclosed |