Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8398430 | 0.81 | CA1 (0.43) | ALDH1A1SMN1; SMN2MEN1CYP1A2CYP2C9 | |
| SCHEMBL7171193 | 0.81 | MEN1 (0.54) | ALDH1A1PKMSMN1; SMN2MEN1CYP1A2 | |
| SCHEMBL7124281 | 0.79 | TERT (0.42) | ALDH1A1SMN1; SMN2MEN1CYP1A2CYP2C9 | |
| SCHEMBL7174642 | 0.77 | KDM4E (0.43) | ALDH1A1SMN1; SMN2MEN1CYP1A2CYP2C9 | |
| SCHEMBL8396114 | 0.77 | ALDH1A1 (0.40) | ALDH1A1PKMSMN1; SMN2MEN1CYP1A2 | |
| SCHEMBL10676572 | 0.76 | ALDH1A1 (0.62) | ALDH1A1PKMSMN1; SMN2MEN1CYP1A2 | |
| SCHEMBL6243924 | 0.72 | ALDH1A1 (0.68) | ALDH1A1PKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8393467 | 0.71 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2MEN1CYP1A2CYP2C9 | |
| SCHEMBL8393470 | 0.68 | POLB (0.38) | ALDH1A1SMN1; SMN2MEN1CYP1A2CYP2C9 | |
| SCHEMBL25669864 | 0.66 | ALDH1A1 (0.41) | ALDH1A1PKMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030040028-A1 | Analgesic screening method and composition | MILLER JAMES L (US) | 2003-02-27 | — | — | US | disclosed |
| US-6489119-B1 | SELECTING ANALGESIC AGENTS BASED ON THEIR SELECTIVE ABILITY TO BLOCK TETRODOTOXIN-INSENSITIVE SODIUM CHANNELS, PARTICULARLY IN COMPARISON TO BLOCKING TETRODOTOXIN-SENSITIVE SODIUM CHANNELS. ALSO DISCLOSED IS A NOVEL CLASS OF COMPOUNDS | ELAN PHARMACEUTICALS, INC. | 2002-12-03 | — | — | US | disclosed |
| EP-0915834-A1 | METHOD AND COMPOSITIONS FOR PRODUCING ANALGESIA | ELAN PHARMACEUTICALS, INC. (US) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997033860-A1 | METHOD AND COMPOSITIONS FOR PRODUCING ANALGESIA | NEUREX CORPORATION (US) | 1997-09-18 | — | — | WO | disclosed |