Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6449508 | 0.83 | LSS (0.43) | GPR119RAB9AENPP2JAK2JAK1 | |
| SCHEMBL6449406 | 0.83 | LSS (0.36) | GPR119RAB9AENPP2JAK2JAK1 | |
| SCHEMBL27747836 | 0.80 | RAB9A (0.43) | HRH2HRH1GNAI3GNAO1GNAI1 | |
| SCHEMBL6449214 | 0.80 | ALDH1A1 (0.37) | HRH2HRH1GPR119RAB9AENPP2 | |
| SCHEMBL6450100 | 0.80 | GPR119 (0.35) | HRH2HRH1GPR119RAB9AENPP2 | |
| SCHEMBL7192232 | 0.73 | LSS (0.45) | GPR119LMNA | |
| SCHEMBL1692765 | 0.72 | RAB9A (0.46) | GPR119RAB9AJAK2JAK1GAA | |
| SCHEMBL10089204 | 0.72 | RAB9A (0.48) | GPR119RAB9ASMN1; SMN2GAA | |
| SCHEMBL1841296 | 0.71 | RAB9A (0.44) | GPR119RAB9AJAK2JAK1GAA | |
| SCHEMBL3132481 | 0.71 | RAB9A (0.44) | GPR119RAB9AJAK2JAK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317432-A1 | PIPERIDINE DERIVATIVES FOR USE AS 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020483-A1 | PIPERIDINE DERIVATIVES FOR USE 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-14 | — | — | WO | disclosed |