Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 17/20 | 0.42 |
| ▸ | CA2 | P00918 | 17/20 | 0.42 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP9 | P14780 | 3/20 | 0.39 |
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
| ▸ | MMP13 | P45452 | 3/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30019489 | 0.98 | THRB (0.46) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL13455184 | 0.79 | CA2 (0.55) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL27241367 | 0.79 | CA1 (0.41) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL17577416 | 0.74 | CA1 (0.36) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL1618550 | 0.74 | CA1 (0.41) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL1618321 | 0.74 | CA1 (0.43) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL7182151 | 0.74 | CA2 (0.46) | CA1CA2 | |
| SCHEMBL1618140 | 0.72 | CA1 (0.47) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL10480408 | 0.72 | CA2 (0.43) | CA1CA2 | |
| SCHEMBL10480417 | 0.72 | CA2 (0.43) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583130-B1 | Substituted with acyl, oxycarbonyl, aminocarbonyl, sulfonyl, or aminosulfonyl; inhibit steroid sulfatase, do not exhibit any estrogenic effect and will not yield any estrogenic products on hydrolysis; treatment of estrogen-dependent tumors | SCHERING AG (DE) | 2003-06-24 | — | — | US | claimed |
| US-6583130-B1 | Substituted with acyl, oxycarbonyl, aminocarbonyl, sulfonyl, or aminosulfonyl; inhibit steroid sulfatase, do not exhibit any estrogenic effect and will not yield any estrogenic products on hydrolysis; treatment of estrogen-dependent tumors | SCHERING AG (DE) | 2003-06-24 | — | — | US | disclosed |