SCHEMBL7174997

SCHEMBL7174997

COc1ccc(-c2c(CNC(=O)O)n(C)c(=O)c3ccc(Cl)cc23)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 6/20 0.54
KCNA5 P22460 1/20 0.51
KCNH2 Q12809 1/20 0.51
CYP3A4 P08684 2/20 0.44
TACR1 P25103 2/20 0.44
PLA2G2A P14555 1/20 0.43
CA1 P00915 2/20 0.43
CA2 P00918 2/20 0.43
CA12 O43570 1/20 0.43
CA3 P07451 1/20 0.43
CA4 P22748 1/20 0.43
CA6 P23280 1/20 0.43
CA5A P35218 1/20 0.43
CA7 P43166 1/20 0.43
CA9 Q16790 1/20 0.43
CA13 Q8N1Q1 1/20 0.43
CA14 Q9ULX7 1/20 0.43
CA5B Q9Y2D0 1/20 0.43
MAPK8 P45983 2/20 0.42
AKR1B10 O60218 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5235258 0.89 DPP4 (0.53) DPP4KCNA5KCNH2TACR1MAPK8
SCHEMBL5237229 0.87 DPP4 (0.56) DPP4CYP3A4TACR1
SCHEMBL5240310 0.85 DPP4 (0.57) DPP4KCNA5KCNH2CYP3A4CA1
SCHEMBL5238106 0.84 DPP4 (0.53) DPP4TACR1
SCHEMBL5238796 0.83 DPP4 (0.58) DPP4KCNA5KCNH2CYP3A4CA1
SCHEMBL7006788 0.82 DPP4 (0.74) DPP4KCNA5KCNH2CYP3A4CA1
Hydrochloric Acid SCHEMBL5240250 0.81 DPP4 (0.72) DPP4KCNA5KCNH2CYP3A4CA1
SCHEMBL5233643 0.81 DPP4 (0.59) DPP4KCNA5KCNH2TACR1MAPK8
SCHEMBL5237066 0.81 DPP4 (0.56) DPP4KCNA5KCNH2TACR1MAPK8
SCHEMBL6110261 0.81 KCNA5 (0.53) DPP4KCNA5KCNH2CYP3A4TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1355886-A1 FUSED HETEROCYCLIC COMPOUNDS Takeda Chemical Industries, Ltd. (JP) 2003-10-29 EP disclosed
WO-2002062764-A1 FUSED HETEROCYCLIC COMPOUNDS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-08-15 WO disclosed