Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8441644 | 0.88 | GPR119 (0.49) | GPR119TSHRALOX15ATMTACR1 | |
| SCHEMBL2950605 | 0.82 | GPR119 (0.46) | GPR119TSHRALOX15ATMCHRM2 | |
| SCHEMBL2952664 | 0.81 | OPRD1 (0.47) | GPR119TSHRALOX15ATMCHRM2 | |
| SCHEMBL972474 | 0.77 | TSHR (0.65) | GPR119TSHRALOX15ATMTACR1 | |
| SCHEMBL21077865 | 0.76 | GPR119 (0.45) | GPR119TSHRALOX15ATMTACR1 | |
| SCHEMBL17269931 | 0.76 | GPR119 (0.50) | GPR119TSHRALOX15ATMCHRM2 | |
| SCHEMBL3246933 | 0.75 | TSHR (0.57) | GPR119TSHRALOX15ATMCHRM2 | |
| SCHEMBL240381 | 0.75 | TSHR (0.57) | GPR119TSHRALOX15ATMCHRM4 | |
| SCHEMBL7839284 | 0.75 | GPR119 (0.46) | GPR119TSHRALOX15TACR1KDM4E | |
| SCHEMBL8202394 | 0.75 | KDM4E (0.50) | GPR119TSHRALOX15ATMCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6579889-B2 | Alzheier's diseases; antiallergens; vision defects; antihistamines; skin disorders | MERCK & CO., INC. | 2003-06-17 | — | — | US | disclosed |
| US-20020019419-A1 | Substituted isonipecotyl derivatives as inhibitors of cell adhesion | MERCK & CO., INC. | 2002-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019419-A1 | Substituted isonipecotyl derivatives as inhibitors of cell adhesion | VCAM1, ICAM1, CD4 | GPR119 249/4885TSHR 3886/4885ALOX15 265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.