Sugi Predict

Sugi Predict / Compounds / SCHEMBL7175604

SCHEMBL7175604

SCHEMBL7175604

Cc1cc(C)c(C(=O)P(=O)(C(=O)c2c(Cl)cccc2Cl)c2ccccc2)c(C)c1C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.36
▸ GAA P10253 2/20 0.36
▸ TP53 P04637 1/20 0.36
▸ KMT2A Q03164 3/20 0.35
▸ PTK2B Q14289 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ SMO Q99835 1/20 0.35
▸ TYK2 P29597 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.34
▸ DOT1L Q8TEK3 1/20 0.34
▸ MEN1 O00255 2/20 0.33
▸ PTGS2 P35354 2/20 0.33
▸ USP2 O75604 1/20 0.33
▸ MT-CO2 P00403 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ TTR P02766 1/20 0.33
▸ PLA2G1B P04054 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ PGR P06401 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7181152 0.95 TYK2 (0.39) MAPTGAATP53KMT2APTK2B
SCHEMBL7188861 0.92 MAPT (0.38) MAPTGAATP53KMT2APTK2B
SCHEMBL7182790 0.91 MAPT (0.35) MAPTGAATP53KMT2ARAB9A
SCHEMBL7181616 0.90 KMT2A (0.36) MAPTGAATP53KMT2ARAB9A
SCHEMBL7177492 0.90 NPC1 (0.33) MAPTGAATP53KMT2ARAB9A
SCHEMBL7184915 0.89 PTGS2 (0.40) KMT2ARAB9AALDH1A1MEN1PTGS2
SCHEMBL7183795 0.88 PTGS2 (0.34) MAPTGAATP53KMT2AALDH1A1
SCHEMBL7180941 0.88 TP53 (0.33) MAPTGAATP53KMT2AALDH1A1
SCHEMBL7183366 0.88 TYK2 (0.36) MAPTGAATP53KMT2ATYK2
SCHEMBL7184875 0.88 ALDH1A1 (0.33) MAPTTP53KMT2ARAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 MAPT 4870/4885GAA 4753/4885TP53 3575/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 MAPT 4859/4885GAA 4793/4885TP53 3524/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.