Sugi Predict

Sugi Predict / Compounds / SCHEMBL7183366

SCHEMBL7183366

SCHEMBL7183366

Cc1cc(C)c(C(=O)P(=O)(C(=S)c2c(C)cccc2Cl)c2ccccc2)c(C)c1C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TYK2 P29597 1/20 0.36
▸ MAPT P10636 3/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ FABP3 P05413 1/20 0.34
▸ FABP4 P15090 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ ITGB1 P05556 3/20 0.34
▸ ITGA4 P13612 3/20 0.34
▸ ITGA2 P17301 1/20 0.34
▸ ITGB7 P26010 1/20 0.34
▸ TRPM4 Q8TD43 1/20 0.33
▸ GAA P10253 2/20 0.33
▸ HPGD P15428 1/20 0.32
▸ KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7181152 0.90 TYK2 (0.39) TYK2MAPTFABP3FABP4ITGB1
SCHEMBL7188244 0.89 TYK2 (0.41) TYK2MAPTALDH1A1L3MBTL1FABP3
SCHEMBL7175917 0.89 TYK2 (0.41) TYK2MAPTALDH1A1L3MBTL1FABP3
SCHEMBL7180603 0.89 TYK2 (0.41) TYK2MAPTALDH1A1L3MBTL1FABP3
SCHEMBL7186804 0.88 MAPT (0.38) TYK2MAPTKDM4EALDH1A1L3MBTL1
SCHEMBL7175604 0.88 MAPT (0.36) TYK2MAPTALDH1A1LMNAITGB1
SCHEMBL7177897 0.85 MAPT (0.38) TYK2MAPTKDM4EALDH1A1L3MBTL1
SCHEMBL7177289 0.84 L3MBTL1 (0.34) MAPTKDM4EALDH1A1L3MBTL1TDP1
SCHEMBL7183686 0.83 TYK2 (0.40) TYK2MAPTALDH1A1FABP3FABP4
SCHEMBL7189057 0.81 ATM (0.41) TYK2KDM4EALDH1A1FABP4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TYK2 1285/4885MAPT 4870/4885KDM4E 3226/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TYK2 1333/4885MAPT 4859/4885KDM4E 2651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.