Sugi Predict

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SCHEMBL7175709

SCHEMBL7175709

Cc1cccc(Cl)c1C(=O)P(=O)(C(=O)c1ccccc1)c1c(C)cc(C(C)(C)C)cc1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TYK2 P29597 1/20 0.39
▸ ALDH1A1 P00352 3/20 0.38
▸ RAB9A P51151 2/20 0.38
▸ L3MBTL1 Q9Y468 2/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ GLA P06280 1/20 0.38
▸ ATM Q13315 1/20 0.38
▸ KCNK9 Q9NPC2 1/20 0.38
▸ LMNA P02545 2/20 0.38
▸ MAPT P10636 2/20 0.37
▸ GAA P10253 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ RXRA P19793 1/20 0.36
▸ RXRB P28702 1/20 0.36
▸ TP53 P04637 3/20 0.36
▸ THRB P10828 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ ESRRG P62508 1/20 0.34
▸ FABP3 P05413 1/20 0.34
▸ FABP4 P15090 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7188961 0.95 ALDH1A1 (0.39) TYK2ALDH1A1RAB9AL3MBTL1NPC1
SCHEMBL7184996 0.91 KCNK9 (0.42) ALDH1A1L3MBTL1KCNK9LMNAMAPT
SCHEMBL7180547 0.88 ALDH1A1 (0.38) ALDH1A1RAB9AL3MBTL1NPC1GLA
SCHEMBL7188949 0.88 ALDH1A1 (0.37) ALDH1A1RAB9AL3MBTL1NPC1GLA
SCHEMBL7187511 0.86 LMNA (0.43) ALDH1A1RAB9AL3MBTL1NPC1GLA
SCHEMBL7175714 0.83 GAA (0.41) TYK2ALDH1A1RAB9AL3MBTL1NPC1
SCHEMBL7180180 0.83 LMNA (0.40) ALDH1A1L3MBTL1KCNK9LMNAMAPT
SCHEMBL7189982 0.81 ALDH1A1 (0.37) ALDH1A1RAB9AL3MBTL1NPC1GLA
SCHEMBL7184398 0.81 LMNA (0.40) ALDH1A1RAB9ANPC1ATMKCNK9
SCHEMBL7181260 0.81 ALDH1A1 (0.38) ALDH1A1KCNK9LMNAMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TYK2 1285/4885ALDH1A1 3416/4885RAB9A 1818/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TYK2 1333/4885ALDH1A1 3984/4885RAB9A 2155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.