Sugi Predict

Sugi Predict / Compounds / SCHEMBL7189982

SCHEMBL7189982

SCHEMBL7189982

COc1cccc(Cl)c1P(=O)(C(=O)c1ccccc1)C(=O)c1c(C)cc(C(C)(C)C)cc1C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.37
▸ KDM4E B2RXH2 3/20 0.37
▸ LMNA P02545 3/20 0.37
▸ PYGL P06737 1/20 0.36
▸ RAB9A P51151 4/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ MAPT P10636 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ NPY1R P25929 1/20 0.35
▸ NPY2R P49146 1/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ POLB P06746 1/20 0.35
▸ NPC1 O15118 3/20 0.34
▸ ATM Q13315 2/20 0.34
▸ KCNK9 Q9NPC2 2/20 0.34
▸ GLA P06280 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ PDE4D Q08499 1/20 0.34
▸ KCNK3 O14649 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182401 0.90 MEN1 (0.40) ALDH1A1KDM4EPYGLRAB9ASMN1; SMN2
SCHEMBL7188949 0.89 ALDH1A1 (0.37) ALDH1A1KDM4ELMNARAB9ASMN1; SMN2
SCHEMBL7188630 0.89 TRPM4 (0.41) ALDH1A1RAB9AMAPTKMT2APOLB
SCHEMBL7180547 0.88 ALDH1A1 (0.38) ALDH1A1KDM4ELMNARAB9ASMN1; SMN2
SCHEMBL7182641 0.88 ATM (0.38) ALDH1A1KDM4ELMNARAB9ASMN1; SMN2
SCHEMBL7735403 0.86 PYGL (0.37) ALDH1A1KDM4ELMNAPYGLRAB9A
SCHEMBL7184398 0.85 LMNA (0.40) ALDH1A1KDM4ELMNARAB9AMAPT
SCHEMBL7175566 0.85 TRPM4 (0.41) ALDH1A1RAB9AMAPTNPC1ATM
SCHEMBL7178228 0.85 CA12 (0.44) ALDH1A1LMNAPYGLRAB9AMAPT
SCHEMBL7186756 0.85 CA12 (0.41) ALDH1A1LMNAPYGLRAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885KDM4E 3226/4885LMNA 3241/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885KDM4E 2651/4885LMNA 3247/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.