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SCHEMBL7175973

SCHEMBL7175973

Cc1cccc(Cl)c1C(=O)C(C(=O)OCC(C)CC(C)(C)C)c1ccccc1.O=[PH3]

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ MMP8 P22894 1/20 0.35
▸ ADRB2 P07550 2/20 0.35
▸ ADRB1 P08588 2/20 0.35
▸ ADRB3 P13945 2/20 0.35
▸ CCR5 P51681 1/20 0.34
▸ NPC1 O15118 2/20 0.33
▸ RAB9A P51151 2/20 0.33
▸ TRPM4 Q8TD43 1/20 0.33
▸ MAPT P10636 2/20 0.33
▸ LMNA P02545 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ HTR1E P28566 1/20 0.33
▸ S1PR3 Q99500 1/20 0.33
▸ UTS2R Q9UKP6 1/20 0.32
▸ HTR1D P28221 2/20 0.32
▸ POLB P06746 2/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ ITGB1 P05556 2/20 0.32
▸ ITGA4 P13612 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182755 0.93 NPC1 (0.36) MMP8ADRB2ADRB1ADRB3NPC1
SCHEMBL7186433 0.92 L3MBTL1 (0.40) L3MBTL1MMP8ADRB2ADRB1ADRB3
SCHEMBL7174628 0.88 ALDH1A1 (0.40) L3MBTL1MMP8ADRB2ADRB1ADRB3
SCHEMBL7174652 0.88 HTR1D (0.35) NPC1RAB9AMAPTHTR1DPOLB
SCHEMBL7184953 0.84 MMP8 (0.50) L3MBTL1MMP8NPC1RAB9ATRPM4
SCHEMBL7189842 0.84 MMP8 (0.37) L3MBTL1MMP8LMNAGAAALDH1A1
SCHEMBL27561257 0.83 ALDH1A1 (0.40) L3MBTL1MMP8ADRB2ADRB1ADRB3
SCHEMBL7189869 0.83 MMP8 (0.36) L3MBTL1MMP8ADRB2ADRB1ADRB3
SCHEMBL7180422 0.83 MMP8 (0.36) L3MBTL1MMP8LMNAALDH1A1
SCHEMBL7175796 0.82 L3MBTL1 (0.41) L3MBTL1MMP8ADRB2ADRB1ADRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 L3MBTL1 302/4885MMP8 4404/4885ADRB2 2200/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 L3MBTL1 126/4885MMP8 4586/4885ADRB2 2462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.