Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7173330 | 0.97 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7175502 | 0.97 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7180535 | 0.97 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7183213 | 0.97 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6119092 | 0.97 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4887030 | 0.97 | ALDH1A1 (0.54) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4887039 | 0.97 | ALDH1A1 (0.54) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7179232 | 0.82 | ALDH1A1 (0.43) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6714110 | 0.82 | KDM4E (0.54) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6714109 | 0.82 | KDM4E (0.54) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1367069-A1 | Process for homo-or copolymerization of conjugated diens | DOW GLOBAL TECHNOLOGIES INC. (US) | 2003-12-03 | — | — | EP | disclosed |