Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7175502 | 0.97 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7173330 | 0.97 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7175999 | 0.97 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7180535 | 0.97 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7183213 | 0.97 | ALDH1A1 (0.51) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4887030 | 0.97 | ALDH1A1 (0.54) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4887039 | 0.97 | ALDH1A1 (0.54) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7179238 | 0.82 | ALDH1A1 (0.43) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6714110 | 0.82 | KDM4E (0.54) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6714109 | 0.82 | KDM4E (0.54) | ALDH1A1ALOX15RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643329-B1 | IN-SITU ACTIVATION OF METAL COMPLEXES USED AS HYDROSILYLATION CATALYSTS | MOMENTIVE PERFORMANCE MAT INC (US) | 2016-07-27 | — | — | EP | disclosed |
| US-8765987-B2 | In-situ activation of metal complexes containing terdentate nitrogen ligands used as hydrosilylation catalysts | CORNELL UNIVERSITY (US) | 2014-07-01 | — | — | US | disclosed |
| EP-2643329-A2 | IN-SITU ACTIVATION OF METAL COMPLEXES USED AS HYDROSILYLATION CATALYSTS | Momentive Performance Materials Inc. (US) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012071358-A2 | IN-SITU ACTIVATION OF METAL COMPLEXES CONTAINING TERDENTATE NITROGEN LIGANDS USED AS HYDROSILYLATION CATALYSTS | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2012-05-31 | — | — | WO | disclosed |
| US-20120130106-A1 | IN-SITU ACTIVATION OF METAL COMPLEXES CONTAINING TERDENTATE NITROGEN LIGANDS USED AS HYDROSILYLATION CATALYSTS | CORNELL UNIVERSITY (US) | 2012-05-24 | — | — | US | disclosed |
| EP-1367069-A1 | Process for homo-or copolymerization of conjugated diens | DOW GLOBAL TECHNOLOGIES INC. (US) | 2003-12-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130106-A1 | IN-SITU ACTIVATION OF METAL COMPLEXES CONTAINING TERDENTATE NITROGEN LIGANDS USED AS HYDROSILYLATION CATALYSTS | TST, TPR, NBAS | ALDH1A1 3950/4885ALOX15 1335/4885RAB9A 2175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.