Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | SHBG | P04278 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7176569 | 1.00 | AR (0.44) | ARNR3C1PGRNR3C2SHBG | |
| SCHEMBL7431433 | 0.76 | SHBG (0.52) | ARNR3C1PGRNR3C2SHBG | |
| SCHEMBL6840979 | 0.74 | CYP3A4 (0.55) | ARNR3C1PGRNR3C2SHBG | |
| SCHEMBL6840982 | 0.74 | CYP3A4 (0.55) | ARNR3C1PGRNR3C2SHBG | |
| SCHEMBL3275154 | 0.73 | LMNA (0.53) | ARNR3C1PGRNR3C2SHBG | |
| Mexrenoate SCHEMBL19874044 | 0.72 | TDP1 (0.59) | ARNR3C1PGRNR3C2SHBG | |
| Mexrenoate SCHEMBL6705068 | 0.72 | TDP1 (0.59) | ARNR3C1PGRNR3C2SHBG | |
| Mexrenoate SCHEMBL6705061 | 0.72 | TDP1 (0.59) | ARNR3C1PGRNR3C2SHBG | |
| Mexrenoate SCHEMBL11692751 | 0.72 | TDP1 (0.59) | ARNR3C1PGRNR3C2SHBG | |
| SCHEMBL7237238 | 0.72 | CYP3A4 (0.45) | ARNR3C1PGRNR3C2SHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280533-A2 | ALDOSTERONE ANTAGONIST COMPOSITION FOR RELEASE DURING ALDOSTERONE ACROPHASE | Pharmacia Corporation (US) | 2003-02-05 | — | — | EP | disclosed |
| EP-1175220-A2 | NANOPARTICULATE EPLERENONE COMPOSITIONS | Pharmacia Corporation (US) | 2002-01-30 | — | — | EP | disclosed |
| WO-2001087284-A2 | ALDOSTERONE ANTAGONIST COMPOSITION FOR RELEASE DURING ALDOSTERONE ACROPHASE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | disclosed |
| WO-2001041770-A2 | NANOPARTICULATE EPLERENONE COMPOSITIONS | PHARMACIA CORPORATION (US) | 2001-06-14 | — | — | WO | disclosed |