Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | BID | P55957 | 3/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.33 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7171425 | 0.97 | KCNH2 (0.37) | KCNH2CYP3A4CYP2D6CYP2C9LIPG | |
| Hydrochloric Acid SCHEMBL7181474 | 0.97 | KCNH2 (0.37) | KCNH2CYP3A4CYP2D6CYP2C9LIPG | |
| Hydrochloric Acid SCHEMBL7176311 | 0.97 | KCNH2 (0.37) | KCNH2CYP3A4CYP2D6CYP2C9LIPG | |
| Hydrochloric Acid SCHEMBL7172221 | 0.97 | KCNH2 (0.37) | KCNH2CYP3A4CYP2D6CYP2C9LIPG | |
| Hydrochloric Acid SCHEMBL7183871 | 0.97 | KCNH2 (0.37) | KCNH2CYP3A4CYP2D6CYP2C9LIPG | |
| Hydrochloric Acid SCHEMBL7184074 | 0.97 | KCNH2 (0.37) | KCNH2CYP3A4CYP2D6CYP2C9LIPG | |
| Hydrochloric Acid SCHEMBL7178930 | 0.91 | GRM5 (0.35) | KCNH2LMNAHTTSMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL7183693 | 0.89 | TLR8 (0.33) | KCNH2CYP3A4CYP2D6CYP2C9LMNA | |
| Hydrochloric Acid SCHEMBL7183137 | 0.89 | TRPV1 (0.34) | KCNH2LIPGLMNAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7183136 | 0.89 | TLR8 (0.33) | KCNH2CYP3A4CYP2D6CYP2C9LIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1367069-A1 | Process for homo-or copolymerization of conjugated diens | DOW GLOBAL TECHNOLOGIES INC. (US) | 2003-12-03 | — | — | EP | disclosed |