Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7179111 | 0.97 | TLR8 (0.33) | TLR8NOS2KCNH2TYRCYP1A2 | |
| Hydrochloric Acid SCHEMBL7176665 | 0.97 | TLR8 (0.33) | TLR8NOS2KCNH2TYRCYP1A2 | |
| Hydrochloric Acid SCHEMBL7188585 | 0.97 | TLR8 (0.33) | TLR8NOS2KCNH2TYRCYP1A2 | |
| Hydrochloric Acid SCHEMBL7175253 | 0.97 | TLR8 (0.33) | TLR8NOS2KCNH2TYRCYP1A2 | |
| Hydrochloric Acid SCHEMBL7178990 | 0.97 | TLR8 (0.33) | TLR8NOS2KCNH2TYRCYP1A2 | |
| Hydrochloric Acid SCHEMBL7172485 | 0.97 | TLR8 (0.33) | TLR8NOS2KCNH2TYRCYP1A2 | |
| Hydrochloric Acid SCHEMBL7179263 | 0.92 | CYP1A2 (0.33) | NOS2CYP1A2NOS1 | |
| Hydrochloric Acid SCHEMBL7185415 | 0.91 | NOS2 (0.36) | TLR8NOS2TYRHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7183136 | 0.90 | TLR8 (0.33) | TLR8NOS2KCNH2TYRHTT | |
| Hydrochloric Acid SCHEMBL7183137 | 0.90 | TRPV1 (0.34) | TLR8KCNH2TYRHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1367069-A1 | Process for homo-or copolymerization of conjugated diens | DOW GLOBAL TECHNOLOGIES INC. (US) | 2003-12-03 | — | — | EP | disclosed |