Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 17/20 | 0.74 |
| ▸ | CA1 | P00915 | 2/20 | 0.74 |
| ▸ | CA2 | P00918 | 2/20 | 0.74 |
| ▸ | CA9 | Q16790 | 2/20 | 0.74 |
| ▸ | ESR1 | P03372 | 1/20 | 0.74 |
| ▸ | CA4 | P22748 | 1/20 | 0.74 |
| ▸ | CA6 | P23280 | 1/20 | 0.74 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.74 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.60 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.60 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11857389 | 0.88 | LMNA (0.72) | STSCA1CA2CA9ESR1 | |
| SCHEMBL11862021 | 0.88 | LMNA (0.72) | STSCA1CA2CA9ESR1 | |
| SCHEMBL11857394 | 0.88 | LMNA (0.72) | STSCA1CA2CA9ESR1 | |
| SCHEMBL28068491 | 0.88 | LMNA (0.72) | STSCA1CA2CA9ESR1 | |
| SCHEMBL4623091 | 0.88 | LMNA (0.72) | STSCA1CA2CA9ESR1 | |
| Emate SCHEMBL6370815 | 0.85 | STS (1.00) | STSCA1CA2CA9ESR1 | |
| Emate SCHEMBL14548146 | 0.85 | STS (1.00) | STSCA1CA2CA9ESR1 | |
| Emate SCHEMBL305660 | 0.85 | STS (1.00) | STSCA1CA2CA9ESR1 | |
| Emate SCHEMBL10062721 | 0.85 | STS (1.00) | STSCA1CA2CA9ESR1 | |
| Emate SCHEMBL29406834 | 0.85 | STS (1.00) | STSCA1CA2CA9ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583130-B1 | Substituted with acyl, oxycarbonyl, aminocarbonyl, sulfonyl, or aminosulfonyl; inhibit steroid sulfatase, do not exhibit any estrogenic effect and will not yield any estrogenic products on hydrolysis; treatment of estrogen-dependent tumors | SCHERING AG (DE) | 2003-06-24 | — | — | US | disclosed |