Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | HPGD | P15428 | 5/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 3/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.53 |
| ▸ | FEN1 | P39748 | 1/20 | 0.53 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL352557 | 0.85 | RAB9A (0.70) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3183222 | 0.84 | ALDH1A1 (0.79) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL668302 | 0.83 | ALDH1A1 (0.62) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18906081 | 0.81 | ALDH1A1 (0.87) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23804626 | 0.81 | HPGD (0.64) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13058838 | 0.81 | POLB (0.64) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3235289 | 0.81 | ALDH1A1 (0.74) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7180515 | 0.80 | ALDH1A1 (0.63) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29119982 | 0.80 | ALDH1A1 (0.50) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27643228 | 0.80 | HPGD (0.63) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1369410-A1 | Process for the stereoselective reduction of derivatives of 4-aryl-4-oxobutyric acid | BAYER AG (DE) | 2003-12-10 | — | — | EP | claimed |
| EP-1369410-A1 | Process for the stereoselective reduction of derivatives of 4-aryl-4-oxobutyric acid | BAYER AG (DE) | 2003-12-10 | — | — | EP | disclosed |
| US-4342690-A | HHYPOTENSIVE AGE TS | AMERICAN CYANAMID COMPANY (US) | 1982-08-03 | — | — | US | disclosed |
| US-4342689-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1982-08-03 | — | — | US | disclosed |
| US-4342691-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1982-08-03 | — | — | US | disclosed |
| US-4299769-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1981-11-10 | — | — | US | disclosed |