Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estradiol Cypionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 7/20 | 0.74 |
| ▸ | LMNA | P02545 | 10/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.74 |
| ▸ | MAPT | P10636 | 8/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.74 |
| ▸ | MEN1 | O00255 | 6/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.74 |
| ▸ | TP53 | P04637 | 4/20 | 0.74 |
| ▸ | PGR | P06401 | 4/20 | 0.74 |
| ▸ | AR | P10275 | 4/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.74 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.74 |
| ▸ | PDE4A | P27815 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.70 |
| ▸ | ATM | Q13315 | 3/20 | 0.70 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.70 |
| ▸ | SHBG | P04278 | 2/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estradiol Cypionate SCHEMBL6195927 | 0.90 | LMNA (0.92) | LMNAKMT2AMAPTCYP3A4ESR1 | |
| Estradiol Cypionate SCHEMBL3199191 | 0.89 | LMNA (0.87) | LMNAKMT2AMAPTCYP3A4ESR1 | |
| Estradiol Benzoate SCHEMBL5885955 | 0.87 | ESR1 (0.93) | LMNAKMT2AMAPTCYP3A4ESR1 | |
| Estradiol Cypionate SCHEMBL28333106 | 0.86 | LMNA (1.00) | LMNAKMT2AMAPTCYP3A4ESR1 | |
| Estradiol Cypionate SCHEMBL12754433 | 0.86 | LMNA (1.00) | LMNAKMT2AMAPTCYP3A4ESR1 | |
| Estradiol Cypionate SCHEMBL29404977 | 0.86 | LMNA (1.00) | LMNAKMT2AMAPTCYP3A4ESR1 | |
| Estradiol Cypionate SCHEMBL41551 | 0.86 | LMNA (1.00) | LMNAKMT2AMAPTCYP3A4ESR1 | |
| Estradiol Cypionate SCHEMBL19236258 | 0.86 | LMNA (1.00) | LMNAKMT2AMAPTCYP3A4ESR1 | |
| Estradiol Cypionate SCHEMBL20130822 | 0.86 | LMNA (1.00) | LMNAKMT2AMAPTCYP3A4ESR1 | |
| SCHEMBL4649449 | 0.85 | MAPT (0.82) | LMNAKMT2AMAPTCYP3A4ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748190-B1 | PROGESTOGEN-FREE FORMULATIONS OF GnRH AND ESTROGEN FOR TREATING BENIGN GYNECOLOGICAL DISORDERS | UNIV SOUTHERN CALIFORNIA (US) | 2003-07-30 | — | — | EP | claimed |