Sugi Predict

Sugi Predict / Compounds / SCHEMBL7180705

SCHEMBL7180705

SCHEMBL7180705

Cc1ccccc1PC(=O)c1c(Cl)cccc1Cl.[LiH]

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.42
▸ FABP3 P05413 1/20 0.41
▸ FABP4 P15090 1/20 0.41
▸ TYK2 P29597 1/20 0.41
▸ HDAC4 P56524 2/20 0.38
▸ TRPM4 Q8TD43 1/20 0.37
▸ S1PR4 O95977 1/20 0.36
▸ KMT2A Q03164 2/20 0.35
▸ PTGS2 P35354 1/20 0.35
▸ RAB9A P51151 2/20 0.35
▸ NPC1 O15118 2/20 0.35
▸ ITGB1 P05556 2/20 0.35
▸ ITGA4 P13612 2/20 0.35
▸ ITGA2 P17301 1/20 0.35
▸ ITGB7 P26010 1/20 0.35
▸ FEN1 P39748 1/20 0.35
▸ HPGD P15428 2/20 0.35
▸ CYP2C9 P11712 1/20 0.34
▸ RORC P51449 1/20 0.34
▸ CES2 O00748 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182835 0.97 FABP3 (0.43) ALDH1A1FABP3FABP4TYK2HDAC4
Lithium SCHEMBL7180715 0.97 ALDH1A1 (0.42) ALDH1A1FABP3FABP4TYK2HDAC4
Lithium SCHEMBL7182848 0.93 FABP3 (0.43) ALDH1A1FABP3FABP4TYK2HDAC4
SCHEMBL7181277 0.90 CA12 (0.42) ALDH1A1FABP4TRPM4KMT2ARAB9A
SCHEMBL7188981 0.87 L3MBTL1 (0.36) ALDH1A1FABP3FABP4HDAC4KMT2A
Lithium SCHEMBL7181285 0.87 CA12 (0.42) ALDH1A1FABP4TRPM4KMT2ARAB9A
Lithium SCHEMBL7188994 0.84 L3MBTL1 (0.36) ALDH1A1FABP3FABP4HDAC4KMT2A
SCHEMBL7179761 0.82 FABP3 (0.46) FABP3FABP4TYK2TRPM4S1PR4
SCHEMBL7182754 0.82 ALDH1A1 (0.45) ALDH1A1FABP3FABP4TYK2HDAC4
SCHEMBL7185635 0.82 ALDH1A1 (0.39) ALDH1A1FABP3FABP4TYK2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885FABP3 3252/4885FABP4 4550/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885FABP3 2807/4885FABP4 4256/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.