Sugi Predict

Sugi Predict / Compounds / Lithium

Lithium

Lithium

SCHEMBL7182848

Cc1ccccc1PC(=O)c1c(C)cccc1Cl.[Li]

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FABP3 P05413 1/20 0.43
▸ FABP4 P15090 1/20 0.43
▸ TYK2 P29597 1/20 0.42
▸ ALDH1A1 P00352 1/20 0.40
▸ TRPM4 Q8TD43 1/20 0.39
▸ ITGB1 P05556 3/20 0.36
▸ ITGA4 P13612 3/20 0.36
▸ ITGA2 P17301 1/20 0.36
▸ ITGB7 P26010 1/20 0.36
▸ HDAC4 P56524 1/20 0.36
▸ RORC P51449 2/20 0.36
▸ CYP2C9 P11712 1/20 0.36
▸ ALDH2 P05091 1/20 0.35
▸ S1PR4 O95977 1/20 0.35
▸ UTS2R Q9UKP6 1/20 0.34
▸ HCRTR1 O43613 1/20 0.34
▸ HCRTR2 O43614 1/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ PTGS2 P35354 1/20 0.34
▸ NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182835 0.97 FABP3 (0.43) FABP3FABP4TYK2ALDH1A1TRPM4
Lithium SCHEMBL7180715 0.97 ALDH1A1 (0.42) FABP3FABP4TYK2ALDH1A1TRPM4
SCHEMBL7180705 0.93 ALDH1A1 (0.42) FABP3FABP4TYK2ALDH1A1TRPM4
Lithium SCHEMBL7188994 0.88 L3MBTL1 (0.36) FABP3FABP4ALDH1A1HDAC4CYP2C9
Lithium SCHEMBL7181285 0.87 CA12 (0.42) FABP4ALDH1A1TRPM4KMT2ANPC1
Lithium SCHEMBL7179768 0.86 FABP3 (0.46) FABP3FABP4TYK2TRPM4ITGB1
Lithium SCHEMBL7183080 0.85 TYK2 (0.39) FABP3FABP4TYK2ALDH1A1TRPM4
Lithium SCHEMBL7189944 0.85 TYK2 (0.39) FABP3FABP4TYK2ALDH1A1TRPM4
SCHEMBL7188981 0.84 L3MBTL1 (0.36) FABP3FABP4ALDH1A1HDAC4CYP2C9
SCHEMBL7181277 0.84 CA12 (0.42) FABP4ALDH1A1TRPM4KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 FABP3 3252/4885FABP4 4550/4885TYK2 1285/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 FABP3 2807/4885FABP4 4256/4885TYK2 1333/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.