Sugi Predict

Sugi Predict / Compounds / SCHEMBL7180942

SCHEMBL7180942

SCHEMBL7180942

O=C(c1c(Cl)cccc1Cl)P(=O)(C(=O)c1c(Cl)c(Cl)cc(Cl)c1Cl)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.39
▸ MAPT P10636 2/20 0.38
▸ PTK2B Q14289 1/20 0.38
▸ TSHR P16473 1/20 0.36
▸ FEN1 P39748 1/20 0.36
▸ SMO Q99835 1/20 0.35
▸ PBRM1 Q86U86 1/20 0.35
▸ DOT1L Q8TEK3 1/20 0.35
▸ JAK2 O60674 2/20 0.35
▸ TYK2 P29597 2/20 0.35
▸ TAS1R3 Q7RTX0 1/20 0.34
▸ TAS1R1 Q7RTX1 1/20 0.34
▸ TAS1R2 Q8TE23 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ APAF1 O14727 1/20 0.34
▸ TDP2 O95551 1/20 0.34
▸ NSD2 O96028 1/20 0.34
▸ ABL1 P00519 1/20 0.34
▸ GALK1 P51570 1/20 0.34
▸ BLM P54132 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7179365 0.90 ALDH1A1 (0.41) ALDH1A1MAPTPTK2BTSHRFEN1
SCHEMBL58730 0.90 ALDH1A1 (0.47) ALDH1A1MAPTPTK2BTSHRFEN1
SCHEMBL7180494 0.90 TYK2 (0.40) ALDH1A1MAPTPTK2BTYK2ABL1
SCHEMBL7189823 0.89 TSHR (0.41) ALDH1A1MAPTPTK2BTSHRFEN1
SCHEMBL7182180 0.87 FABP3 (0.36) ALDH1A1MAPTTYK2APAF1ABL1
SCHEMBL7180783 0.87 CA12 (0.42) MAPTCA2
SCHEMBL7183633 0.86 ALDH1A1 (0.40) ALDH1A1MAPTPTK2BFEN1SMO
SCHEMBL7181377 0.83 TYK2 (0.40) TYK2KDM4E
SCHEMBL7180802 0.83 CA12 (0.44) ALDH1A1MAPTKDM4EKMT2ACA2
SCHEMBL7174830 0.82 MEN1 (0.39) ALDH1A1MAPTAPAF1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885MAPT 4870/4885PTK2B 1875/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885MAPT 4859/4885PTK2B 2406/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.