SCHEMBL7183633

SCHEMBL7183633

O=C(c1c(Cl)cccc1Cl)P(=O)(C(=O)c1c(Cl)cc(Cl)cc1Cl)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.40
PTPRC P08575 1/20 0.40
MAPT P10636 2/20 0.39
PTK2B Q14289 1/20 0.39
GAA P10253 3/20 0.38
FABP3 P05413 1/20 0.37
FABP4 P15090 1/20 0.37
FEN1 P39748 1/20 0.37
SMO Q99835 1/20 0.36
SPR P35270 1/20 0.36
PBRM1 Q86U86 1/20 0.36
DOT1L Q8TEK3 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
KMT2A Q03164 1/20 0.35
STK39 Q9UEW8 1/20 0.35
JAK2 O60674 1/20 0.35
TYK2 P29597 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL58730 0.92 ALDH1A1 (0.47) ALDH1A1MAPTPTK2BFABP3FABP4
SCHEMBL7174754 0.92 FABP3 (0.40) PTPRCMAPTPTK2BGAAFABP3
SCHEMBL7174651 0.88 FABP3 (0.39) PTPRCMAPTFABP3FABP4KDM4E
SCHEMBL7190112 0.88 FABP4 (0.44) FABP4STK39
SCHEMBL7180942 0.86 ALDH1A1 (0.39) ALDH1A1MAPTPTK2BFEN1SMO
SCHEMBL7179365 0.85 ALDH1A1 (0.41) ALDH1A1MAPTPTK2BFABP3FABP4
SCHEMBL7175972 0.84 TYK2 (0.40) PTPRCKDM4ESTK39TYK2
SCHEMBL7177535 0.84 CA12 (0.44) ALDH1A1MAPTFABP4MEN1NPC1
SCHEMBL7189823 0.84 TSHR (0.41) ALDH1A1MAPTPTK2BFEN1PBRM1
SCHEMBL7188746 0.84 MEN1 (0.39) PTPRCMAPTGAAKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885PTPRC 905/4885MAPT 4870/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885PTPRC 670/4885MAPT 4859/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.