SCHEMBL7181291

SCHEMBL7181291

Cc1cc(NS(=O)(=O)c2ccc(Cl)cc2)ccc1O

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CES1 P23141 1/20 0.62
CYP19A1 P11511 1/20 0.59
HSD17B3 P37058 1/20 0.57
HSD17B2 P37059 1/20 0.57
FFAR4 Q5NUL3 1/20 0.56
HSP90AA1 P07900 1/20 0.55
HSP90AB1 P08238 1/20 0.55
HTT P42858 2/20 0.54
ALDH1A1 P00352 2/20 0.54
TDP1 Q9NUW8 1/20 0.54
PKM P14618 3/20 0.54
HKDC1 Q2TB90 1/20 0.54
WDR5 P61964 1/20 0.52
GAA P10253 2/20 0.52
ALOX15 P16050 1/20 0.52
HSD17B10 Q99714 1/20 0.52
ATIC P31939 1/20 0.52
MAPT P10636 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7175892 0.88 CES1 (0.62) CES1CYP19A1HSD17B3HSD17B2FFAR4
SCHEMBL13997280 0.84 CYTH2 (0.71) HSD17B2FFAR4HSP90AA1HSP90AB1HTT
SCHEMBL16187955 0.82 UQCRB (0.64) HSD17B2HTTALDH1A1PKMGAA
SCHEMBL17174222 0.81 CES1 (0.66) CES1CYP19A1FFAR4ALDH1A1TDP1
SCHEMBL7174361 0.81 LMNA (0.58) CES1CYP19A1HSD17B3HSD17B2HSP90AA1
Acetic Acid SCHEMBL3426591 0.81 CYTH2 (0.66) HSD17B2FFAR4HSP90AA1HSP90AB1HTT
SCHEMBL13629423 0.81 CES1 (0.60) CES1CYP19A1FFAR4ALDH1A1TDP1
SCHEMBL13615103 0.79 CES1 (0.58) CES1CYP19A1FFAR4ALDH1A1TDP1
SCHEMBL27852760 0.79 FFAR4 (0.64) CES1CYP19A1HSD17B3HSD17B2FFAR4
SCHEMBL2474197 0.78 CES1 (1.00) CES1CYP19A1HTTALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579829-B2 Aromatic sulfonamide compound MITSUI CHEMICALS, INC. (JP) 2003-06-17 US disclosed
EP-1138517-A2 Developer composition and heat sensitive recording material Mitsui Chemicals, Inc. (JP) 2001-10-04 EP disclosed