Sugi Predict

Sugi Predict / Compounds / SCHEMBL7181406

SCHEMBL7181406

SCHEMBL7181406

CCC(C)[PH](=O)c1ccccc1C(=O)c1c(Cl)cccc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TAS1R3 Q7RTX0 1/20 0.39
▸ TAS1R1 Q7RTX1 1/20 0.39
▸ TAS1R2 Q8TE23 1/20 0.39
▸ RORC P51449 4/20 0.36
▸ CNR2 P34972 1/20 0.36
▸ GABRP O00591 2/20 0.35
▸ GABRD O14764 2/20 0.35
▸ GABRA1 P14867 2/20 0.35
▸ GABRB1 P18505 2/20 0.35
▸ GABRG2 P18507 2/20 0.35
▸ GABRB3 P28472 2/20 0.35
▸ GABRA5 P31644 2/20 0.35
▸ GABRA3 P34903 2/20 0.35
▸ GABRA2 P47869 2/20 0.35
▸ GABRB2 P47870 2/20 0.35
▸ GABRA4 P48169 2/20 0.35
▸ GABRE P78334 2/20 0.35
▸ GABRA6 Q16445 2/20 0.35
▸ GABRG1 Q8N1C3 2/20 0.35
▸ GABRG3 Q99928 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7175837 0.92 RORC (0.41) TAS1R3TAS1R1TAS1R2RORCCNR2
SCHEMBL7182252 0.89 TGM2 (0.40) RORCRAB9ALMNACES2CES1
SCHEMBL7189502 0.85 KMT2A (0.34) CNR2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7181405 0.80 KMT2A (0.39) CYP2C9LMNAHPGDTP53MEN1
SCHEMBL10626896 0.79 ALDH1A1 (0.42) RORCGABRPGABRDGABRA1GABRB1
SCHEMBL7188463 0.78 MEN1 (0.31) ALDH1A1MEN1KMT2A
SCHEMBL7186971 0.77 TP53 (0.32) CYP1A2CYP3A4CYP2C9CYP2C19TP53
SCHEMBL7189077 0.74 POLB (0.33) RORCCNR2GABRPGABRDGABRA1
SCHEMBL8899649 0.74 KMT2A (0.41) RORCGABRPGABRDGABRA1GABRB1
SCHEMBL7181140 0.74 ALDH1A1 (0.43) TAS1R3TAS1R1TAS1R2CNR2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TAS1R3 2990/4885TAS1R1 3374/4885TAS1R2 3865/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TAS1R3 3176/4885TAS1R1 3927/4885TAS1R2 4103/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.